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Genetic and Epigenetic Intersections in COVID-19-Associated Cardiovascular Disease: Emerging Insights and Future

Hussein Sabit1, Borros Arneth2, Afaf Altrawy1

  • 1Department of Medical Biotechnology, College of Biotechnology, Misr University for Science and Technology, Giza P.O. Box 77, Egypt.

Biomedicines
|February 26, 2025
PubMed

Insights

This study investigates microRNAs (miRNAs) as biomarkers to predict antiplatelet therapy response in COVID-19 patients with cardiovascular disease (CVD). Identifying miRNA signatures can personalize treatment and improve outcomes for thrombotic events.

Area of Science:

  • Cardiovascular Medicine
  • Molecular Biology
  • Infectious Diseases

Background:

  • COVID-19 exacerbates cardiovascular disease (CVD) through inflammation and endothelial dysfunction.
  • Antiplatelet therapies (e.g., ticagrelor, clopidogrel) are crucial for managing thrombotic risks in these patients.
  • MicroRNAs (miRNAs) regulate key pathways in platelet function, inflammation, and vascular homeostasis.

Purpose of the Study:

  • To explore specific miRNAs (miR-223, miR-126) as predictive biomarkers for antiplatelet therapy response in COVID-19 patients with CVD.
  • To understand the role of miRNA-mediated pathways in SARS-CoV-2-induced cardiovascular complications.
  • To identify miRNA signatures for optimizing antiplatelet treatment strategies.

Main Methods:

  • Investigated the role of specific microRNAs (miR-223, miR-126) in COVID-19 patients with cardiovascular disease.
  • Analyzed miRNA expression patterns in relation to antiplatelet therapy (ticagrelor, clopidogrel) efficacy.
  • Explored miRNA-mediated mechanisms underlying SARS-CoV-2's impact on cardiovascular function.

Main Results:

  • Potential identification of miR-223 and miR-126 as biomarkers for predicting antiplatelet therapy response.
  • Elucidation of miRNA's role in modulating platelet function and inflammation during COVID-19.
  • Insights into how SARS-CoV-2 exacerbates CVD via cytokine storms and endothelial damage.

Conclusions:

  • miRNA profiling can enhance personalized antiplatelet therapy for COVID-19 patients with CVD.
  • Understanding miRNA-mediated pathways offers novel therapeutic targets for cardiovascular complications.
  • This research aims to reduce mortality and improve outcomes in COVID-19-associated cardiovascular events.

Keywords:
COVID-19cardiovascular diseaseclopidogrel efficacyendothelial dysfunctionmiRNA biomarkersticagrelor resistance

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