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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

378
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
378
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

112
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
112
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

157
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
157
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

294
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
294
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

89
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
89
Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

297
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
297

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Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Laboratory Tests in Inflammatory Bowel Disease: An Evidence-Based Approach to Daily Practice.

Katelin Durham1,2, Tyler Atagozli3, David E Elliott1,2

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.

Biomedicines
|February 26, 2025
PubMed
Summary

Laboratory tests are crucial for managing inflammatory bowel diseases (IBD), aiding in diagnosis, monitoring treatment response, and preventing complications from medications like biologics.

Keywords:
Crohn’s diseaseanti-drug antibodiesinflammatory bowel diseasetherapeutic drug monitoringtrough levelulcerative colitis

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Last Updated: Jul 3, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
08:27

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

Area of Science:

  • Gastroenterology
  • Clinical Immunology
  • Internal Medicine

Background:

  • Inflammatory bowel diseases (IBD) are chronic gastrointestinal disorders with relapsing-remitting courses.
  • Current IBD management relies on medications including steroids, immune modulators, biologics, and small molecules, which carry risks of severe toxicities.
  • Laboratory tests are vital for IBD diagnosis, disease activity assessment, monitoring treatment efficacy and toxicity, and detecting complications like infections and nutritional deficiencies.

Purpose of the Study:

  • To explore the range of laboratory tests used in IBD management.
  • To summarize the clinical applications of these tests in daily practice.
  • To highlight updates in therapeutic drug monitoring (TDM) for biologic therapies in IBD.

Main Methods:

  • Review of established and emerging laboratory tests for IBD.
  • Analysis of the role of laboratory tests in diagnosis, disease monitoring, and toxicity surveillance.
  • Focus on the evolving utility of therapeutic drug monitoring (TDM) in the context of biologic therapies.

Main Results:

  • Laboratory tests aid in assessing disease activity, monitoring medication response and toxicity, and screening for infections (e.g., tuberculosis, hepatitis B) and deficiencies (e.g., vitamin B12).
  • Established laboratory practices are complemented by newer tests, such as TDM for biologics, which is an area of ongoing research and clinical evolution.
  • While not replacing clinical assessment, imaging, endoscopy, or histology, laboratory tests serve as valuable adjuncts in comprehensive IBD care.

Conclusions:

  • Laboratory tests are indispensable tools in the comprehensive management of IBD, supporting clinical decision-making across various aspects of patient care.
  • Routine laboratory monitoring is essential for optimizing therapeutic benefits while mitigating risks associated with immunosuppressive therapies.
  • The integration of advanced laboratory diagnostics, including TDM, represents a significant development in personalizing IBD treatment strategies.