Related Experiment Video
Updated: May 6, 2026
Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
Published on: December 6, 2016
Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case-Control Study
Aikaterini Kyriakopoulou1, Kyriakos Samikos2, Aikaterini Kanavaki2
1Third Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Objective:
To investigate the clinical characteristics associated with the presence of LSV at birth.
Design:
Prospective 1:1 case-control study.
Setting:
Two tertiary neonatal units in Athens, Greece.
Patients:
Premature neonates (≤36 weeks gestational age) who underwent cerebral ultrasound within the first 3 weeks of life, where LSV was detected.
Main Outcome Measure:
Associations between LSV and clinical characteristics at birth. Both unmatched and matched analyses stratifying the study population by gestational week were conducted. Two-sided p-values were computed using the likelihood ratio test.
Results:
This study included 166 participants (83 cases and 83 controls). Neonates with LSV exhibited more concurrent cerebral findings, notably periventricular echogenicity. LSV was correlated with higher z-scores for head circumference and body length. LSV was not associated with congenital CMV.
Conclusions:
This study indicated a relationship between LSV and increased head circumference and body length. Further research is warranted to explore LSV's pathophysiological mechanisms.
