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Cost-Effectiveness Analysis of Photobiomodulation After Third Molar Extraction for Pain Control
Thalita Molinos Campos1, Mayra Costanti Vilela Campos1, Raquel Agnelli Mesquita-Ferari1,2
1Postgraduate Program in Biophotonics Medicine, Nove de Julho University (UNINOVE), Rua Vergueiro, 235/249-Liberdade, São Paulo 01504-001, SP, Brazil.
International Journal of Environmental Research and Public Health
|February 26, 2025
Summary
Photobiomodulation significantly reduces pain after third molar extraction. While more expensive, this laser therapy offers greater effectiveness, making it a valuable clinical option when weighing cost against patient benefit.
Area of Science:
- Dental Surgery
- Pain Management
- Health Economics
Background:
- Third molar extraction is a common dental procedure with potential negative post-surgical effects.
- Conventional treatments using anti-inflammatory drugs can cause unwanted side effects.
- Photobiomodulation offers a promising alternative for managing post-surgical pain and inflammation.
Purpose of the Study:
- To evaluate the cost-effectiveness of photobiomodulation therapy following third molar extraction.
- To compare the effectiveness and cost of photobiomodulation versus conventional treatments.
Main Methods:
- A systematic review of 15 studies and a meta-analysis of 8 studies were conducted.
- Effectiveness was measured using the visual analog scale for pain.
- Costs were determined based on Brazilian health system data and common clinical practices.
Main Results:
- Photobiomodulation demonstrated a significant reduction in post-surgical pain on the second day (MD, -1.15; 95% CI, -1.73, -0.57).
- The laser treatment group showed higher effectiveness but also incurred a higher cost (USD 34.62) compared to the control group.
- A trade-off exists between increased cost and enhanced pain relief with photobiomodulation.
Conclusions:
- Photobiomodulation is a cost-effective option for managing pain after third molar extraction, offering superior pain reduction.
- The decision to use photobiomodulation should involve a clinical assessment of the cost versus the benefit of improved pain control.
- This therapy presents a valuable alternative for patients seeking reduced pain and discomfort post-surgery.

