Related Experiment Video
Updated: May 25, 2025

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety
Published on: November 11, 2022
Analysis of Anxiety Disorders and Post-Traumatic Stress Disorders for Screening Anxiolytic Drugs and Linking
Anna Kozłowska1, Wan-Jiun Ma2, Bai-Chuang Shyu3
1Department of Human Physiology and Pathophysiology, Collegium Medicum, University of Warmia and Mazury, Warszawska Av, 30, 10-082 Olsztyn, Poland.
Abstract:
How to determine suitable animal models of anxiety disorders and post-traumatic stress disorders (PTSD) for screening anxiolytic drugs and linking preclinical and clinical research is a crucial issue. This review paper provides background knowledge and critical determination to the animal models for discussing this issue. Moreover, this article analyzes the characteristics, properties, advantages, and disadvantages of various animal models of anxiety disorders and PTSD. It offers an overview of the pathophysiology, treatments, prevalence, and symptoms of anxiety disorders in the clinics. Furthermore, it comprehensively discusses pharmacological treatments and neural mechanisms, as well as the types and properties of the animal models of anxiety disorders in shaping and testing anxiety behaviors. In light of the previous literature discussion, we can understand the different functions of the animal models of anxiety disorders and PTSD to help us link preclinical and clinical research. Animal models are used in advanced drug discovery programs, specifically in psychiatry and neuroscience research. The challenge for the future will be to keep pace with developing the appropriate animal models of anxiolytic drugs to improve the translation of large datasets obtained to clinics.
Related Concept Videos
Anxiolytic Drugs: Overview
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
Anxiolytic Drugs: Benzodiazepines and Buspirone
Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Generalized Anxiety Disorder
Drug Therapy
Antianxiety Medications
Preclinical Development: Overview

