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The Crosstalk Between Endothelial Cells, Smooth Muscle Cells, and Macrophages in Atherosclerosis

Sihe Gong1,2, Yanni Li1,2, Kaijie Yan1,2

  • 1School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China.

International Journal of Molecular Sciences
|February 26, 2025
PubMed

Insights

This review explores cellular metabolism in atherosclerosis (AS), focusing on endothelial cells, smooth muscle cells, and macrophages. It highlights cellular crosstalk and metabolic derangements in AS progression and therapeutic strategies.

Area of Science:

  • Cardiovascular Biology
  • Cellular Metabolism
  • Immunology

Background:

  • Atherosclerosis (AS) is a chronic inflammatory vascular disease.
  • Cellular metabolism significantly influences AS pathogenesis.
  • Endothelial cells, smooth muscle cells, and macrophages are key players in AS.

Purpose of the Study:

  • To analyze the roles of endothelial cells, smooth muscle cells, and macrophages in AS.
  • To summarize the crosstalk between these cells and its consequences.
  • To identify potential therapeutic targets for AS.

Main Methods:

  • Literature review of cellular metabolism in AS.
  • Analysis of genome-wide association study data.
  • Examination of cellular crosstalk mechanisms.

Main Results:

  • AS involves complex interactions between endothelial cells, smooth muscle cells, and macrophages.
  • Metabolic derangements in these cells contribute to AS progression.
  • Crosstalk between cell types influences disease exacerbation and regression.

Conclusions:

  • Understanding cellular metabolism and crosstalk is crucial for AS research.
  • Targeting cellular metabolism and interactions offers therapeutic potential.
  • Three-cell co-culture models and extracellular vesicles are important for future AS studies.

Keywords:
atherosclerosisendothelial cellsmacrophagessmooth muscle cells

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