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Soluplus®-Based Pharmaceutical Formulations: Recent Advances in Drug Delivery and Biomedical Applications
Nerea Guembe-Michel1, Paul Nguewa2, Gustavo González-Gaitano1
1Department of Chemistry, School of Science, University of Navarra, 31080 Pamplona, Spain.
International Journal of Molecular Sciences
|February 26, 2025
Summary
Soluplus (SLP), a versatile polymer carrier, enhances drug solubility and bioavailability for improved therapeutic efficacy. This review highlights SLP
Area of Science:
- Pharmaceutical Science
- Materials Science
- Biomedical Engineering
Background:
- Poor water solubility of active pharmaceutical ingredients (APIs) significantly limits their therapeutic efficacy and bioavailability.
- Soluplus (SLP), an amphiphilic graft copolymer, is emerging as a key excipient to address these solubility challenges.
- SLP's unique physicochemical properties enable the formation of stable amorphous drug dispersions.
Purpose of the Study:
- To review the formulation strategies employing Soluplus (SLP) for advanced drug delivery.
- To highlight the role of SLP in overcoming common pharmaceutical formulation challenges.
- To explore the biomedical applications of SLP in various therapeutic areas.
Main Methods:
- Review of literature on formulation techniques utilizing Soluplus (SLP).
- Examination of methods including hot-melt extrusion, spray drying, and electrospinning.
- Analysis of SLP's application in capsule and tablet formulations.
Main Results:
- Soluplus (SLP) effectively enhances drug solubility and bioavailability through amorphous solid dispersions.
- Various formulation methods demonstrate SLP's adaptability for controlled release and improved drug targeting.
- SLP shows promise in enhancing the delivery of antitumoral, anti-inflammatory, antimicrobial, and antiparasitic drugs.
Conclusions:
- Soluplus (SLP) is a versatile excipient capable of overcoming significant drug formulation challenges.
- SLP facilitates advanced drug delivery systems with improved therapeutic outcomes.
- Further exploration of SLP in diverse biomedical applications is warranted.
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