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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Correction: Mahmud et al. Thymoquinone Attenuates NF-κβ Signalling Activation in Retinal Pigment Epithelium Cells Under AMD-Mimicking Conditions. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 11473.

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Related Experiment Video

Updated: May 25, 2025

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
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Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

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Circulating RNA Markers Associated with Adenoma-Carcinoma Sequence in Colorectal Cancer.

Li Ah Kim1, Jin Han1, Tae Il Kim2

  • 1Department of Biomedical Laboratory Science, College of Software and Digital Healthcare Convergence, Yonsei University Mirae Campus, Wonju 26493, Republic of Korea.

International Journal of Molecular Sciences
|February 26, 2025
PubMed
Summary
This summary is machine-generated.

New circulating RNA biomarkers show promise for early colorectal cancer detection. These markers reflect immune responses during the adenoma-carcinoma sequence, offering a non-invasive diagnostic approach.

Keywords:
RNARNA transcriptsadenoma–carcinoma sequencecolorectal cancerdifferentially expressed genes

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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

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Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Colorectal cancer (CRC) follows an adenoma-carcinoma sequence (ACS), crucial for early detection.
  • Current surveillance relies on tissue sampling, limiting accurate staging.
  • Liquid biopsies (ctDNA, RNA) offer non-invasive alternatives but detect passive markers, not active biological processes.

Purpose of the Study:

  • Identify circulating RNA biomarkers reflecting immune responses during ACS progression.
  • Develop non-invasive tools for early CRC detection and diagnosis.

Main Methods:

  • Analyzed blood samples from 160 individuals across five groups: CRC, advanced adenoma, non-advanced adenoma, symptomatic non-disease control, and healthy control.
  • Employed RNA sequencing, gene ontology, and protein-protein interaction analyses.
  • Identified stage-specific circulating RNA transcripts.

Main Results:

  • IFI27 linked to symptomatic non-disease control.
  • DEFA4 associated with non-advanced adenoma.
  • MPO identified in advanced adenoma.
  • CD177 detected in colorectal cancer patients.
  • Stage-specific RNA markers correlate with host immune responses.

Conclusions:

  • Circulating RNA biomarkers reflect host immune responses during colorectal cancer progression.
  • These markers hold potential for early CRC detection and non-invasive diagnosis.
  • Advances liquid biopsy utility in CRC screening and clinical management.