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Conjugated Proteins

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...

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Cell-Free Production of Proteoliposomes for Functional Analysis and Antibody Development Targeting Membrane Proteins

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Development of Stable, Maleimide-Functionalized Peptidoliposomes Against SARS-CoV-2.

Olga Michel¹, Aleksandra Kaczorowska^1,2, Lucyna Matusewicz¹

¹Department of Cytobiochemistry, Faculty of Biotechnology, University of Wrocław, F. Joliot Curie 14a, 50-383 Wrocław, Poland.

International Journal of Molecular Sciences

|February 26, 2025

Summary

Researchers developed maleimide-functionalized liposomes to deliver SARS-CoV-2-binding peptides for COVID-19 treatment. This nanocarrier platform aims for enhanced stability and homogeneity, offering a universal approach for antiviral drug development.

Keywords:

SARS-CoV-2 decoy receptors extrusion high-pressure homogenization liposomes maleimide microfluidization peptidoliposomes

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Area of Science:

Nanotechnology
Drug Delivery
Virology

Background:

Despite extensive research, effective COVID-19 treatments remain limited, particularly for vulnerable populations.
Existing therapies face challenges in clinical translation and efficacy.
There is a critical need for novel therapeutic strategies against SARS-CoV-2.

Purpose of the Study:

To develop and optimize maleimide-functionalized liposomes as a drug delivery platform.
To immobilize and stabilize a peptide with high affinity for SARS-CoV-2.
To create a stable and homogeneous nanocarrier for potential COVID-19 therapeutics.

Main Methods:

Step-by-step development of maleimide-functionalized liposomes.
Optimization of lipid composition and formation conditions for PEGylated liposomes.
Decoration of liposomes with a SARS-CoV-2-binding peptide.

Main Results:

Demonstrated a process for creating homogeneous and stable maleimide-functionalized liposomes.
Successfully decorated liposomes with a SARS-CoV-2-binding peptide.
Established a foundation for a potential antiviral nanocarrier system.

Conclusions:

Maleimide-functionalized liposomes offer a promising platform for developing COVID-19 therapies.
The developed nanocarrier technology can be adapted for various antiviral agents.
Further optimization is needed to meet drug candidate requirements for stability and efficacy.