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Enhancing Galantamine Distribution in Rat Brain Using Microplasma-Assisted Nose-to-Brain Drug Delivery.

Abubakar Hamza Sadiq1, Md Jahangir Alam2, Farhana Begum2

  • 1Graduate School of Science and Technology, Shizuoka University, Johoku, Chuo-ku, Hamamatsu 432-8561, Japan.

International Journal of Molecular Sciences
|February 26, 2025
PubMed
Summary

Non-thermal plasma treatment enhances nose-to-brain drug delivery for Alzheimer's disease. A novel spiral plasma device improved galantamine distribution in rat brains, offering a potential non-invasive treatment approach.

Keywords:
DBD microplasmaMALDI-IMSgalantamine hydrobromidenon-thermal plasmanose-to-brain drug delivery

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Pharmacology

Background:

  • Nose-to-brain (N2B) drug delivery bypasses the blood-brain barrier for treating brain diseases.
  • Nasal absorption limitations hinder effective N2B drug delivery.
  • Non-thermal plasma (NTP) shows promise for enhancing in vitro drug delivery.

Purpose of the Study:

  • To investigate if NTP treatment enhances in vivo N2B delivery of galantamine for Alzheimer's disease (AD).
  • To evaluate a novel spiral dielectric barrier discharge (DBD) microplasma device for N2B drug delivery.

Main Methods:

  • A spiral DBD microplasma device was designed and inserted 2 mm into the rat nasal cavity.
  • The device was activated for 4 minutes, followed by immediate galantamine hydrobromide administration.
  • Galantamine distribution in the rat brain was analyzed using MALDI-imaging mass spectrometry (MALDI-IMS).

Main Results:

  • Plasma-treated rats exhibited significantly higher galantamine distribution in both brain hemispheres compared to controls.
  • The spiral DBD microplasma demonstrated effective drug distribution enhancement.
  • MALDI-IMS successfully visualized and quantified drug distribution in brain tissues.

Conclusions:

  • Spiral DBD microplasma is a novel design for dielectric barrier discharge.
  • This NTP-based technique offers a potential non-invasive method to enhance brain drug distribution.
  • The findings suggest a promising approach for improving N2B drug delivery in neurological disorders like AD.