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CSE/H2S Signaling Pathways in Enhancing Muscle Function and Insulin Sensitivity During Exercise.
Miaomiao Xu1,2, Xiaoguang Liu3, Danting Hu1
1School of Physical Education and Health, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
International Journal of Molecular Sciences
|February 26, 2025
Summary
Exercise enhances metabolic health by activating the cystathionine γ-lyase (CSE)/hydrogen sulfide (H2S) pathway. This pathway improves muscle function, insulin sensitivity, and glucose metabolism, offering potential for exercise supplements.
Area of Science:
- Exercise physiology
- Molecular biology
- Metabolic health
Background:
- Exercise is vital for metabolic health, muscle function, and insulin sensitivity, crucial for preventing type 2 diabetes.
- The cystathionine γ-lyase (CSE)/hydrogen sulfide (H2S) pathway is increasingly recognized for its role in exercise-induced adaptations.
- Understanding H2S in muscle physiology is key to optimizing exercise benefits.
Purpose of the Study:
- To review the role of the CSE/H2S pathway in exercise-induced metabolic and muscular adaptations.
- To explore H2S metabolism, distribution, and its influence on muscle contraction, repair, and protein synthesis.
- To discuss the potential of H2S donors as exercise supplements for enhanced performance and metabolic health.
Main Methods:
- Comprehensive literature review of existing research on CSE/H2S and exercise.
- Analysis of molecular and physiological mechanisms linking H2S to muscle function and insulin sensitivity.
- Examination of multi-omics data and current research advancements.
Main Results:
- CSE/H2S signaling is a key regulator of exercise adaptations, influencing muscle contraction, repair, and protein synthesis.
- H2S modulates insulin signaling, glucose uptake, and lipid metabolism, improving insulin sensitivity.
- H2S donors show promise as supplements to enhance exercise performance and metabolic health.
Conclusions:
- The CSE/H2S pathway is a critical target for optimizing exercise benefits and improving metabolic health.
- Further mechanistic studies and clinical applications of H2S are warranted.
- Targeting H2S offers therapeutic potential for metabolic diseases and exercise enhancement.
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