Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

56
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
56
Liver Regeneration01:24

Liver Regeneration

3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
Liver Physiology01:30

Liver Physiology

407
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
407
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

930
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
930
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

79
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
79

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Arterial Tissue Gene Expression Associated With Telomere Length Attrition in Coronary Artery Disease.

Journal of lipid and atherosclerosis·2026
Same author

Comparative analysis of pathways induced by TMAO and TNF-α in human microvascular endothelial cells.

Scientific reports·2026
Same author

Intrinsic changes in cell differentiation and identity drive impaired wound healing in aged female murine skin.

Biogerontology·2025
Same author

Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination.

NPJ vaccines·2025
Same author

Sexual dimorphism in the association of umbilical cord blood lipidome with abdominal fat in early childhood.

BMC medicine·2025
Same author

ZHX3 interacts with CEBPB to repress hepatic gluconeogenic gene expression and uric acid secretion.

PNAS nexus·2025

Related Experiment Video

Updated: May 25, 2025

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

745

Current Therapeutic Landscape for Metabolic Dysfunction-Associated Steatohepatitis.

Arun George Devasia1,2, Adaikalavan Ramasamy2, Chen Huei Leo3

  • 1Science, Math & Technology, Singapore University of Technology & Design, Singapore 487372, Singapore.

International Journal of Molecular Sciences
|February 26, 2025
PubMed
Summary

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health issue affecting over 30% of people. This review explores MASLD pathogenesis and current/investigational therapies for MASLD and its severe form, MASH.

Keywords:
metabolic dysfunction-associated steatohepatitismetabolic dysfunction-associated steatotic liver diseasenon-alcoholic fatty liver diseasetherapeutics

More Related Videos

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.0K
Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
08:58

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Published on: March 11, 2017

15.8K

Related Experiment Videos

Last Updated: May 25, 2025

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

745
Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.0K
Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
08:58

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Published on: March 11, 2017

15.8K

Area of Science:

  • Hepatology
  • Metabolic Diseases
  • Gastroenterology

Background:

  • Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally.
  • Affecting over 30% of the population, MASLD is characterized by hepatic steatosis linked to metabolic dysfunction.
  • It can progress to metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, cirrhosis, liver failure, and cancer.

Purpose of the Study:

  • To provide an overview of MASLD pathogenesis.
  • To evaluate current therapeutic strategies for MASLD.
  • To review pharmacological agents under investigation for MASLD and MASH.

Main Methods:

  • Literature review of pathogenesis.
  • Analysis of existing MASLD and MASH therapies.
  • Survey of clinical trials for novel pharmacological treatments.

Main Results:

  • MASLD involves hepatic steatosis and metabolic risk factors.
  • The "multiple-hits" concept suggests dietary, metabolic, and genetic factors contribute to oxidative stress and inflammation.
  • Numerous pharmacological agents are in clinical trials for MASLD/MASH.

Conclusions:

  • Understanding MASLD pathogenesis is crucial for effective treatment.
  • Current research focuses on targeting metabolic dysfunction and inflammation.
  • Promising new therapies are emerging for MASLD and MASH.