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Current Therapeutic Landscape for Metabolic Dysfunction-Associated Steatohepatitis
Arun George Devasia1,2, Adaikalavan Ramasamy2, Chen Huei Leo3
1Science, Math & Technology, Singapore University of Technology & Design, Singapore 487372, Singapore.
International Journal of Molecular Sciences
|February 26, 2025
Summary
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health issue affecting over 30% of people. This review explores MASLD pathogenesis and current/investigational therapies for MASLD and its severe form, MASH.
Area of Science:
- Hepatology
- Metabolic Diseases
- Gastroenterology
Background:
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally.
- Affecting over 30% of the population, MASLD is characterized by hepatic steatosis linked to metabolic dysfunction.
- It can progress to metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, cirrhosis, liver failure, and cancer.
Purpose of the Study:
- To provide an overview of MASLD pathogenesis.
- To evaluate current therapeutic strategies for MASLD.
- To review pharmacological agents under investigation for MASLD and MASH.
Main Methods:
- Literature review of pathogenesis.
- Analysis of existing MASLD and MASH therapies.
- Survey of clinical trials for novel pharmacological treatments.
Main Results:
- MASLD involves hepatic steatosis and metabolic risk factors.
- The "multiple-hits" concept suggests dietary, metabolic, and genetic factors contribute to oxidative stress and inflammation.
- Numerous pharmacological agents are in clinical trials for MASLD/MASH.
Conclusions:
- Understanding MASLD pathogenesis is crucial for effective treatment.
- Current research focuses on targeting metabolic dysfunction and inflammation.
- Promising new therapies are emerging for MASLD and MASH.
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