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Updated: May 25, 2025

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Chr23-miR-200s and Dmrt1 Control Sexually Dimorphic Trade-Off Between Reproduction and Growth in Zebrafish.

Si Ge1, Ying Liu1, Haoran Huang2

  • 1Hubei Hongshan Laboratory, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China.

International Journal of Molecular Sciences
|February 26, 2025
PubMed
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Sexually dimorphic growth and reproduction in zebrafish are controlled by chr23-miR-200s and dmrt1. These genes regulate stat5b, impacting growth and reproductive traits in both sexes.

Area of Science:

  • * Developmental Biology
  • * Endocrinology
  • * Molecular Genetics

Background:

  • * A fundamental trade-off exists between reproduction and growth across animal species.
  • * Significant sex-based differences in reproduction and growth are observed in fish.
  • * The underlying molecular mechanisms driving these sexually dimorphic traits remain largely unclear.

Purpose of the Study:

  • * To elucidate the molecular mechanisms governing the trade-off between reproduction and growth in zebrafish.
  • * To identify key genes and regulatory pathways involved in sexually dimorphic growth and reproduction.

Main Methods:

  • * Gene knockout (KO) and transgenic zebrafish models were utilized.
  • * Expression analysis of chr23-miR-200s, dmrt1, and stat5b.
Keywords:
Dmrt1growthmiR-200reproductionsexual dimorphismtrade-off

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  • * Investigation of gene regulation via 3'UTR and promoter targeting.

    • Main Results:

    • * Knockout of chr23-miR-200s impaired reproduction and increased growth in female zebrafish.
    • * Knockout of dmrt1 impaired reproduction and increased growth in male zebrafish.
    • * Stat5b was identified as a direct downstream target of both chr23-miR-200s and Dmrt1, mediating growth effects.

    Conclusions:

    • * A regulatory model is proposed where chr23-miR-200s and Dmrt1 control the sexually dimorphic trade-off between reproduction and growth.
    • * Stat5b plays a crucial role in mediating the growth-promoting effects observed in the KO models.
    • * This study provides novel insights into the genetic regulation of fundamental life-history traits.