Opiate regulation of mesolimbic serotonin release: in vivo semiderivative electrochemical analyses

The effect of a pharmacologically effective dose of d-morphine sulfate on serotonin release from nucleus accumbens of male, Sprague-Dawley rats was studied. In vivo electrochemical evidence showed that the reference exogenous opiate, morphine, after intraperitoneal administration, significantly increased basal nucleus accumbens serotonin release over control values. These data show a mesolimbic opiate-serotonergic interaction in rat brain.