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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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Bidirectional Interplay Among Non-Coding RNAs, the Microbiome, and the Host During Development and Diseases
Shanshan Nai1, Jiaxian Song1, Wenting Su1
1State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Genes
|February 26, 2025
Summary
Non-coding RNAs (ncRNAs) and gut microbiome interactions are crucial in health and disease. Understanding their crosstalk offers new diagnostic and therapeutic strategies for conditions like cancer and IBD.
Area of Science:
- Molecular Biology
- Microbiology
- Genetics
Background:
- Non-coding RNAs (ncRNAs) and gut microbiome dysbiosis are implicated in host development and disease.
- A bidirectional interplay exists between ncRNAs and the gut microbiome.
Purpose of the Study:
- To review molecular mechanisms of crosstalk between ncRNAs, particularly microRNAs (miRNAs), and the gut microbiome.
- To explore this interaction in development and diseases including colorectal cancer, IBD, neurological disorders, obesity, and cardiovascular disease.
Main Methods:
- Literature review of current research on ncRNA-microbiome interactions.
- Analysis of molecular mechanisms driving this crosstalk.
Main Results:
- ncRNAs and gut microbes engage in complex molecular crosstalk.
- This interaction influences host development and pathogenesis of various diseases.
Conclusions:
- Understanding ncRNA-gut microbiome interplay is key for novel biomarkers and therapeutics.
- Potential clinical applications include ncRNA mimics, antisense oligonucleotides, small molecules, probiotics, prebiotics, and dietary interventions.
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