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Updated: May 25, 2025
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Identification and Expression Patterns of Critical Genes Related to Coat Color in Cashmere Goats
Dubala Wu1, Jing Fan1, Yue Pang1
1College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.
Genes
|February 26, 2025
Summary
This study identified key genes regulating cashmere goat coat color, finding TYRP1, TYR, DCT, and PMEL crucial for black color and ASIP and AHCY for white. These findings offer molecular markers for cashmere goat breeding.
Area of Science:
- Animal Genetics
- Molecular Biology
- Biotechnology
Background:
- Cashmere goat coat color impacts breed optimization and economic value.
- Understanding the genetic basis of coat color is essential for selective breeding programs.
Purpose of the Study:
- To identify key genes responsible for cashmere goat coat color variation.
- To provide molecular markers for improving cashmere goat breeding strategies.
Main Methods:
- Transcriptome sequencing of skin samples from goats with distinct coat colors (white, black, light brown).
- Bioinformatics analysis to screen for differentially expressed genes (DEGs).
- Validation using quantitative real-time PCR (qRT-PCR) and immunofluorescence.
Main Results:
- Identified 1153 DEGs involved in melanin biosynthesis pathways.
- Constructed a gene interaction network highlighting critical coat color-related genes.
- Found high expression of TYRP1, TYR, DCT, and PMEL in black goats, and ASIP, AHCY in white goats.
Conclusions:
- TYRP1, TYR, DCT, and PMEL are pivotal for black coat color formation in cashmere goats.
- ASIP and AHCY play significant roles in regulating white coat color in cashmere goats.
- These identified genes serve as valuable molecular markers for cashmere goat breeding.
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