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Updated: May 25, 2025
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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
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Chromatin Remodulator CHD4: A Potential Target for Cancer Interception
Krishnendu Goswami1, Karthikkumar Venkatachalam1, Surya P Singh1
1Center for Cancer Prevention and Drug Development, Stephenson Cancer Center, Hem-Onc Section, Department of Medicine, University of Oklahoma HSC, Oklahoma City, OK 73104, USA.
Genes
|February 26, 2025
Summary
Chromodomain helicase DNA-binding 4 (CHD4) influences cancer development by altering gene accessibility. This chromatin remodulator is crucial for transcriptional reprogramming, impacting tumor cell proliferation and DNA damage responses.
Area of Science:
- Molecular Biology
- Genetics
- Cancer Biology
Background:
- Cancer development involves genetic alterations and changes in gene network regulation.
- Nucleosome remodeling ATPases, like CHD4, are key in controlling gene accessibility within the nucleus.
- Chromodomain helicase DNA-binding 4 (CHD4) is an ATP-dependent chromatin remodulator involved in various cellular processes.
Purpose of the Study:
- To review and synthesize existing data on the role of CHD4 in cancer.
- To highlight CHD4's function in chromatin accessibility and transcriptional regulation in the context of cancer.
Main Methods:
- Literature review of studies investigating CHD4 in cancer.
- Analysis of CHD4's molecular domains and protein interactions.
- Examination of CHD4's involvement in cancer progression, proliferation, DNA damage response, and immune modulation.
Main Results:
- CHD4 possesses multiple domains for nucleosome mobilization and histone binding.
- CHD4 is a critical component of Nucleosome Remodeling and Deacetylase (NuRD) complexes, facilitating transcriptional reprogramming.
- Data indicate CHD4's significant role in tumor cell proliferation, DNA damage responses, and immune modulation.
Conclusions:
- CHD4-mediated chromatin accessibility is fundamental for transcriptional reprogramming.
- This reprogramming is intrinsically linked to tumor cell proliferation and overall cancer development.
- CHD4 represents a significant target for understanding and potentially treating cancer.
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