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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Related Experiment Video

Updated: May 25, 2025

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Unveiling Racial Disparities in Localized Prostate Cancer: A Systems-Level Exploration of the lncRNA Landscape.

Rebecca A Morgan1, E Starr Hazard2, Stephen J Savage3,4

  • 1Faculty of Medicine, Health and Life Sciences, School of Biological Sciences, Institute for Global Food Security (IGFS), Queen's University Belfast (QUB), Belfast BT9 5DL, UK.

Genes
|February 26, 2025
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) play a key role in prostate cancer (PC) racial disparities, particularly in immune response. Identified lncRNAs may offer new biomarkers and therapeutic targets for African descent (AF) men.

Keywords:
biomarkersdifferential gene expressiongene regulatory networksimmune responseinflammationlong non-coding RNAs (lncRNAs)prostate cancerracial disparitiesvitamin D supplementation

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RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level
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Area of Science:

  • Genomics and Molecular Biology
  • Cancer Research
  • Immunology

Background:

  • Prostate cancer (PC) exhibits significant racial disparities, with higher incidence and mortality in men of African descent (AF) compared to European descent (EU).
  • The underlying biological mechanisms contributing to these disparities are not fully understood.
  • Long non-coding RNAs (lncRNAs) are emerging as critical regulators of gene expression and immune processes, potentially influencing PC disparities.

Purpose of the Study:

  • To investigate the regulatory role of lncRNAs in localized PC in AF men relative to EU men.
  • To assess the involvement of lncRNAs in immune response and inflammation within PC racial disparities.
  • To explore the impact of vitamin D supplementation on lncRNA expression in AF PC patients.

Main Methods:

  • A systems biology approach was utilized to analyze differentially expressed (DE) lncRNAs in PC.
  • Immune-related pathways were investigated using over-representation analysis of lncRNA-mRNA networks.
  • lncRNA expression was examined in relation to vitamin D supplementation in AF PC patients.

Main Results:

  • Specific lncRNAs implicated in immune response and inflammation in AF men were identified.
  • A significant number of top-ranked lncRNAs showed strong interactions with immune-related genes.
  • Pathway analysis indicated lncRNA regulatory roles in antigen processing, chemokine signaling, and ribosome pathways.

Conclusions:

  • lncRNAs play a pivotal role in PC racial disparities, primarily through immune modulation.
  • The identified lncRNAs represent potential biomarkers for PC.
  • These lncRNAs may serve as therapeutic targets to address racial disparities in PC outcomes.