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Hidradenitis Suppurativa Is Associated with an Increased Risk of Adverse Cardiac Events and All-Cause Mortality

Thomas Z Rohan1,2, Ramsay Hafer1,2, Teresa Duong1,2

  • 1Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Journal of Clinical Medicine
|February 26, 2025
PubMed

Insights

Hidradenitis suppurativa (HS) patients face significantly higher risks for major adverse cardiac events (MACEs) and all-cause mortality compared to healthy individuals. Early screening and management of cardiovascular risk factors in HS patients are crucial.

Area of Science:

  • Cardiology
  • Dermatology
  • Epidemiology

Background:

  • Hidradenitis suppurativa (HS) is linked to increased major adverse cardiac events (MACEs).
  • Existing research suggests a higher cardiovascular disease burden in HS patients.
  • Further investigation is needed to clarify the association between HS and cardiovascular outcomes.

Purpose of the Study:

  • To investigate the association between hidradenitis suppurativa (HS) and major adverse cardiac events (MACEs).
  • To evaluate the risk of various cardiovascular diseases in HS patients.
  • To compare cardiovascular disease rates in HS patients against healthy and psoriasis controls.

Main Methods:

  • Retrospective cohort study using the TriNetX electronic health records database.
  • Matching HS patients with healthy and psoriasis controls based on demographics and cardiovascular risk factors.
  • Comparative analysis of cardiovascular disease incidence and all-cause mortality rates.

Main Results:

  • HS patients exhibited significantly higher risks for myocardial infarction, ischemic stroke, heart failure, MACEs, and all-cause mortality compared to healthy controls.
  • Even after adjusting for cardiovascular risk factors, HS patients showed increased risks for all investigated cardiovascular diseases versus healthy and psoriasis controls.
  • HS patients had a 2.06-fold increased risk of myocardial infarction and a 2.21-fold increased risk of heart failure compared to healthy controls.

Conclusions:

  • Hidradenitis suppurativa (HS) is associated with elevated rates of cardiovascular diseases, including MACEs.
  • The findings underscore the importance of cardiovascular risk assessment in HS patients.
  • Proactive management of modifiable cardiovascular risk factors is recommended for individuals with HS.

Keywords:
cardiovascular diseasehidradenitis suppurativainflammatory skin diseasespsoriasis

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