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Relationship of Tumor Localization and Lipid Parameters with Survival in Patients with Colorectal Cancer

  • 0Department of Medical Oncology, Medical Park Bahcelievler Hospital, Istanbul 34180, Türkiye.
Journal of Clinical Medicine +

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February 26, 2025

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February 26, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

High-density lipoprotein cholesterol (HDL-C) and a lower total cholesterol to HDL-C ratio are linked to better survival in colorectal cancer (CRC) patients. These lipid profiles may serve as important prognostic indicators for CRC outcomes.

Area Of Science

  • Oncology
  • Metabolic Medicine
  • Clinical Research

Background

  • Colorectal cancer (CRC) presents a significant global health burden.
  • Dyslipidemia, a metabolic disorder, is implicated in CRC progression, but its precise role alongside tumor location and patient survival remains debated.
  • Understanding the interplay between lipid profiles and CRC is crucial for improving patient outcomes.

Purpose Of The Study

  • To investigate the association between blood lipid parameters (total cholesterol, triglycerides, LDL-C, HDL-C) and overall survival (OS) in colorectal cancer patients.
  • To explore how tumor location (right-sided vs. left-sided) influences the relationship between lipid profiles and CRC prognosis.
  • To identify independent predictors of OS in CRC patients based on clinical, pathological, and lipid data.

Main Methods

  • Retrospective analysis of 126 colorectal cancer patients diagnosed between 2017 and 2024.
  • Exclusion of patients with comorbidities affecting lipid metabolism or on lipid-lowering drugs.
  • Statistical evaluation using Kaplan-Meier and Cox regression models to assess overall survival, considering lipid profiles and tumor location.

Main Results

  • Higher high-density lipoprotein cholesterol (HDL-C) levels and a lower total cholesterol/HDL-C ratio were significantly associated with improved overall survival (OS) (p=0.004 and p=0.016, respectively).
  • These associations remained significant across early- and advanced-stage colorectal cancer.
  • Specific lipid level thresholds for LDL-C, HDL-C, and TC/HDL-C were correlated with better OS depending on tumor location (right vs. left colon).
  • Multivariate analysis identified age, stage, HDL-C, and TC/HDL-C as independent predictors of OS.

Conclusions

  • Lipid profiles, particularly HDL-C and the TC/HDL-C ratio, show potential as prognostic factors in colorectal cancer.
  • The findings suggest a link between lipid metabolism and CRC progression that warrants further investigation.
  • Future research should incorporate molecular and genetic analyses to elucidate the underlying mechanisms connecting lipid metabolism and CRC outcomes.

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