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Updated: May 25, 2025

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Polyphenol-Based Prevention and Treatment of Cancer Through Epigenetic and Combinatorial Mechanisms

Neha Singaravelan1, Trygve O Tollefsbol2,3,4,5

  • 1Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Nutrients
|February 26, 2025
PubMed

Insights

Combining polyphenols like curcumin, resveratrol, and epigallocatechin gallate offers synergistic anti-cancer effects. These polyphenol combinations show enhanced efficacy as a chemotherapeutic strategy compared to individual compounds.

Area of Science:

  • Oncology
  • Pharmacology
  • Epigenetics

Background:

  • Polyphenols exhibit anti-cancer properties by inhibiting DNA methyltransferase (DNMT) and histone deacetylase (HDAC), reducing inflammation, and inducing cell cycle arrest.
  • Research on individual polyphenols' anti-cancer potential is extensive, but studies on their combined effects are limited.

Purpose of the Study:

  • To review the synergistic and additive anti-cancer effects of combining common polyphenols.
  • To explore polyphenol combinations as a viable chemotherapeutic option for cancer treatment.

Main Methods:

  • Literature review focusing on the combinatorial effects of curcumin, resveratrol, and epigallocatechin gallate.
  • Analysis of studies reporting on apoptosis induction, colony formation, migration, tumor suppression, cell viability, angiogenesis, and epigenetic modifications.

Main Results:

  • Combinations of curcumin, resveratrol, and epigallocatechin gallate demonstrated synergistic and additive anti-cancer activities.
  • These combinations effectively induced apoptosis, inhibited colony formation and migration, suppressed tumors, reduced cell viability and angiogenesis, and induced epigenetic modifications.

Conclusions:

  • Polyphenol combinations, particularly curcumin, resveratrol, and epigallocatechin gallate, offer enhanced anti-cancer efficacy compared to individual agents.
  • Optimized concentrations of polyphenol combinations represent a promising and more effective chemotherapeutic strategy for cancer treatment.
Keywords:
cancercombinationdietary polyphenolsepigenetics

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