Anticancer and Antioxidant Effects of Bioactive Peptides from Black Soldier Fly Larvae (Hermetia illucens)
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View abstract on PubMed
Summary
This summary is machine-generated.Black soldier fly larvae (BSFL) peptides show promise for cancer prevention. The study found these bioactive peptides possess antioxidant, anti-inflammatory, and antimutagenic properties, with potential anticancer effects. Further in vivo research is needed for clinical applications.
Area Of Science
- Biochemistry
- Molecular Biology
- Nutraceuticals
Background
- Insect protein hydrolysates exhibit biological activities, with black soldier fly larvae (BSFL) notable for antioxidant properties.
- Limited research exists on BSFL-derived bioactive peptides and their cancer chemopreventive potential.
Purpose Of The Study
- To evaluate antioxidant, anti-inflammatory, antimutagenic, and anticancer activities of BSFL-derived bioactive peptides.
- To explore the molecular mechanisms underlying these activities.
Main Methods
- Extraction and hydrolysis of alkali-soluble BSFL protein (ASBP) using Alcalase and bromelain.
- Assessment of antioxidant activity (FRAP, ABTS, DPPH), anti-inflammatory effects (nitric oxide in RAW 264.7 cells), antimutagenicity (Ames test), and anticancer activity (CCK-8 assays).
- Fractionation by molecular weight, mechanistic studies (microarray, Western blot), and peptide identification (LC-MS/MS).
Main Results
- ASBP-Alcalase hydrolysate (ASBP-AH) showed optimal antioxidant activity; the >30 kDa fraction had the highest antioxidant capacity.
- The <3 kDa fraction (ASBP-AH3) demonstrated significant antimutagenic effects, reduced nitric oxide production, and decreased colon cancer cell viability.
- ASBP-AH3 modulated SKP2/p21/cyclin D1 pathways, with peptides rich in hydrophobic and charged amino acids.
Conclusions
- BSFL-derived bioactive peptides show potential as multifunctional agents for cancer chemoprevention.
- Further in vivo studies are necessary to validate their clinical applications.
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