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MOTS-c Levels and Sarcopenia Risk in Chronic Peritoneal Dialysis Patients: A Pilot Study
Mariateresa Zicarelli1, Marta Greco1,2, Stefanos Roumeliotis3
1Department of Health Sciences, Magna-Graecia University, 88100 Catanzaro, Italy.
Medicina (Kaunas, Lithuania)
|February 26, 2025
Summary
Sarcopenia risk is high in end-stage kidney disease (ESKD) patients on peritoneal dialysis (PD). Mitochondrial peptide MOTS-c levels are altered in PD, potentially contributing to sarcopenia risk and impacting muscle performance.
Area of Science:
- Nephrology
- Gerontology
- Molecular Biology
Background:
- Sarcopenia is prevalent in end-stage kidney disease (ESKD) patients undergoing peritoneal dialysis (PD).
- MOTS-c, a mitochondrial peptide, influences muscle growth and its levels are dysregulated in ESKD.
Purpose of the Study:
- To investigate MOTS-c balance in ESKD patients on PD.
- To determine the association between MOTS-c levels and sarcopenia risk in this cohort.
Main Methods:
- Serum, urine, and dialysate MOTS-c levels were measured in 32 chronic PD patients.
- Sarcopenia risk was assessed using the SARC-F tool, anthropometry, and physical performance tests.
Main Results:
- Patients with high sarcopenia risk exhibited lower serum MOTS-c (sMOTS-c) and higher dialysate MOTS-c (dMOTS-c), indicating increased peritoneal clearance.
- sMOTS-c correlated positively with muscle performance, while dMOTS-c and the d/s MOTS-c ratio correlated negatively.
- MOTS-c demonstrated diagnostic potential, especially when combined with physical and anthropometric data, for identifying high-risk PD patients.
Conclusions:
- Chronic PD may disrupt MOTS-c balance, potentially increasing sarcopenia risk.
- Further research is needed to validate MOTS-c as a biomarker for sarcopenia risk stratification in PD patients.
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