Related Experiment Video
Updated: Jun 28, 2026
09:01
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 11, 2013
Preventing RSV Infection in Children: Current Passive Immunizations and Vaccine Development.
Pius I Babawale1, Iván Martínez-Espinoza1, Alaine' M Mitchell1
1Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
Pathogens (Basel, Switzerland)
|February 26, 2025
Summary
Respiratory syncytial virus (RSV) causes severe illness in vulnerable groups. While vaccines exist for adults and pregnant women, this review covers passive immunizations and infant vaccine development for RSV.
Area of Science:
- Virology and Immunology
- Vaccine Development
- Pediatric Infectious Diseases
Background:
- Human respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in infants, the elderly, and immunocompromised individuals.
- Past vaccine development efforts in the 1960s were unsuccessful due to enhanced disease in vaccinated children.
- Recent progress has yielded RSV vaccines for older adults and pregnant women, but infant vaccines remain unavailable.
Purpose of the Study:
- To review current passive immunization strategies for respiratory syncytial virus (RSV) in infants.
- To summarize ongoing research and development efforts for an infant RSV vaccine.
- To highlight the unmet need for a protective RSV vaccine in the pediatric population.
Main Methods:
- Literature review of existing passive immunization data for RSV.
- Analysis of ongoing clinical trials and research pipelines for infant RSV vaccines.
- Synthesis of information on historical vaccine development challenges and recent advancements.
Main Results:
- Passive immunization with monoclonal antibodies provides short-term protection against RSV.
- Several promising vaccine candidates targeting RSV are in various stages of development for infants.
- Challenges remain in achieving safe and effective long-term immunity in infants.
Conclusions:
- Passive immunizations offer a current, albeit temporary, solution for RSV prevention in infants.
- Continued research and development are crucial to bring a safe and effective RSV vaccine to infants.
- Successful infant RSV vaccination would significantly reduce childhood morbidity and mortality.
Related Concept Videos
01:51Vaccinations
43.7K
Overview
43.7K
01:03Rous Sarcoma Virus (RSV) and Cancer
4.9K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
4.9K
01:31Active versus Passive Immunity
531
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
531
01:22Development of Immunocompetence
282
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
282
01:25Immunodeficiency Diseases
895
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
895
01:30Pneumonia V: Nursing management and Prevention
1.8K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
1.8K