Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

UV–Vis Spectrometers01:14

UV–Vis Spectrometers

1.3K
The absorbance of UV and visible (UV–visible) radiations is measured using a UV–visible spectrophotometer. Deuterium lamps, which emit UV radiation, and tungsten lamps, which produce radiation in the visible region, are used as light sources in UV–visible spectrophotometers. A monochromator or prism is used for diffraction grating, i.e., to split the incoming radiation into different wavelengths. A system of slits is used to focus the desired wavelength on the sample cell.
1.3K
Ultraviolet and Visible (UV–Vis) Spectroscopy: Overview01:02

Ultraviolet and Visible (UV–Vis) Spectroscopy: Overview

2.5K
Ultraviolet–visible (UV–visible or UV–Vis) spectroscopy is an analytical technique that investigates the interaction between matter and UV–Vis light within the electromagnetic spectrum. This method is widely used for its versatility, simplicity, and relatively quick data acquisition, making it valuable for both qualitative and quantitative analysis. When UV–Vis radiation passes through a material,  molecules absorb light depending on the energy required for...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting the compressibility and compactibility profiles of pharmaceutical active ingredients for design of multi-component tablets.

International journal of pharmaceutics·2026
Same author

Hot-melt extruded ibuprofen ternary solid dispersions using in-line UV-Vis: Impact of an ionizable polymer on thermodynamics and dissolution.

International journal of pharmaceutics: X·2026
Same author

Pharmacy Undergraduate Education: Can Student Primary Care Placements Add Value to Learning and Teaching?

Clinics and practice·2026
Same author

High-Resolution <sup>1</sup>H NMR Investigation of the Speciation Status of Nickel(II) and Copper(II) Ions in a Cell Culture Medium: Relevance to Their Toxicological Actions.

Molecules (Basel, Switzerland)·2026
Same author

Quality by digital design to accelerate sustainable medicines development.

International journal of pharmaceutics·2025
Same author

Photobiomodulation LED Devices for Home Use: Design, Function and Potential: A Pilot Study.

Dentistry journal·2025

Related Experiment Video

Updated: May 25, 2025

UV-Vis Spectroscopic Characterization of Nanomaterials in Aqueous Media
05:16

UV-Vis Spectroscopic Characterization of Nanomaterials in Aqueous Media

Published on: October 25, 2021

9.4K

Enhancing Process Control and Quality in Amorphous Solid Dispersions Using In-Line UV-Vis Monitoring of L* as a

Mariana Bezerra1, Juan Almeida2, Matheus de Castro3

  • 1GlaxoSmithKline, David Jack Centre, Harris Lane, Ware SG12 0GX, UK.

Pharmaceutics
|February 26, 2025
PubMed
Summary
This summary is machine-generated.

This study optimized amorphous solid dispersion (ASD) extrusion using a quality by design approach. In-line UV-Vis spectroscopy effectively monitored product quality in real-time, ensuring consistency and reducing waste.

Keywords:
Kollidon® VA64amorphous solid dispersions (ASD)hot melt extrusion (HME)in-line UV–Vis spectroscopypiroxicamprincipal component analysis (PCA)quality by design (QbD)

More Related Videos

Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization
09:35

Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization

Published on: December 25, 2017

28.2K
Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels
11:34

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Published on: September 8, 2016

10.2K

Related Experiment Videos

Last Updated: May 25, 2025

UV-Vis Spectroscopic Characterization of Nanomaterials in Aqueous Media
05:16

UV-Vis Spectroscopic Characterization of Nanomaterials in Aqueous Media

Published on: October 25, 2021

9.4K
Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization
09:35

Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization

Published on: December 25, 2017

28.2K
Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels
11:34

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Published on: September 8, 2016

10.2K

Area of Science:

  • Pharmaceutical Manufacturing
  • Process Analytical Technology (PAT)
  • Quality by Design (QbD)

Background:

  • Sequential design of experiments (DoE) was applied within the quality by design (QbD) framework.
  • The focus was on optimizing extrusion processes through screening, optimization, and robustness testing.

Purpose of the Study:

  • To demonstrate the application of DoE and QbD for extrusion process optimization.
  • To utilize in-line UV-Vis spectroscopy as a Process Analytical Technology (PAT) tool.
  • To monitor critical quality attributes (CQAs) of amorphous solid dispersion (ASD) extrusion products.

Main Methods:

  • An in-line UV-Vis PAT system was implemented.
  • Lightness (L*) was monitored as a critical quality attribute for piroxicam ASD extrusion products.
  • Sequential design of experiments (DoE) guided the optimization and robustness testing.

Main Results:

  • In-line UV-Vis monitoring of L* effectively ensured ASD quality and uniformity.
  • L* variations provided real-time insights into physical appearance and process stability, indicating issues like phase separation or bubble formation.
  • This technique enabled timely interventions and automated adjustments for consistent product quality.

Conclusions:

  • In-line UV-Vis spectroscopy is a valuable PAT tool for hot melt extrusion.
  • It enhances critical quality attribute assessment in amorphous solid dispersion manufacturing.
  • This approach improves manufacturing efficiency, reliability, and adherence to quality target product profiles (QTPPs).