Advancements in the Application of Numerical Simulation During Tablet Compaction

Background: Numerical simulation is a technique that utilizes electronic computers to combine concepts of the discrete element method (DEM), finite element method (FEM), computational fluid dynamics (CFD), etc., and express simulated behaviors utilizing numerical computations and images. Compaction is the main process of tablet manufacturing; most of the current studies have focused on macroscopic compaction and tablet characterization, while the internal stress state and microstructure changes as a result of the compaction process are not well understood. Therefore, an in-depth understanding of the flow and compaction behavior of pharmaceutical powders is essential for the analysis and control of the compaction process. Methods: Current research shows that compaction is shifting from macroscopic behavior toward internal microscopic behavior using numerical simulation technology. Results: This review focuses on the application of various numerical simulation technologies during compaction and the contact model, or the constitutive equation commonly used in numerical simulation. In addition, the difficulties of numerical simulation technology in calibrating powder parameters and the limitations of the current research are also discussed. Conclusions: Numerical simulation research in medicine and other fields will continue to flourish as numerical simulation technology advances, attracting more and more researchers using it effectively.