Leukocyte Count in Solid Organ Transplant Recipients After SARS-CoV-2 mRNA Vaccination and Infection
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View abstract on PubMed
Summary
This summary is machine-generated.COVID-19 vaccination in solid organ transplant (SOT) recipients did not lower leukocyte counts. However, SARS-CoV-2 infection was linked to a higher risk of decreased leukocyte counts in these vulnerable patients.
Area Of Science
- Immunology
- Infectious Diseases
- Transplantation
Background
- Solid organ transplant (SOT) recipients face severe COVID-19 risks.
- Vaccination is crucial but may cause side effects like decreased leukocyte counts.
- Understanding these effects in SOT recipients is vital.
Purpose Of The Study
- To assess the prevalence and incidence of decreased leukocyte counts post-SARS-CoV-2 mRNA vaccination in SOT recipients.
- To compare leukocyte count changes after vaccination versus SARS-CoV-2 infection.
- To evaluate the association between vaccination/infection and decreased leukocyte counts.
Main Methods
- Linear mixed models analyzed leukocyte count changes before and after vaccine doses.
- Prevalence of decreased leukocyte counts was determined pre- and post-vaccination and pre- and post-infection.
- Self-controlled case series analysis assessed the risk of decreased leukocyte counts after vaccination or infection.
Main Results
- In 228 SOT recipients, vaccination did not alter leukocyte counts or their prevalence.
- No association was found between SARS-CoV-2 mRNA vaccination and decreased leukocyte counts (IRR: 0.6; P=0.461).
- SARS-CoV-2 infection significantly increased the risk of decreased leukocyte counts (IRR: 7.1; P<0.001).
Conclusions
- SARS-CoV-2 mRNA vaccination is safe regarding leukocyte counts in SOT recipients.
- Vaccination does not increase the risk or prevalence of decreased leukocyte counts.
- SARS-CoV-2 infection poses a significant risk for decreased leukocyte counts in SOT recipients.
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