The Role of Plant Virus-like Particles in Advanced Drug Delivery and Vaccine Development: Structural Attributes and...

Area of Science:

• Biotechnology
• Biomedical Engineering
• Virology

Background:

• Plant virus-like particles (pVLPs) are an underutilized alternative to traditional VLPs.
• Plant viruses are biocompatible and safe due to long-term human dietary exposure.
• pVLPs offer cost-effective and scalable production via plant-based systems.

Purpose of the Study:

• To provide a practical guide for selecting pVLPs based on critical design factors.
• To explore how pVLP characteristics influence cellular interactions for biomedical applications.
• To review pVLP production scalability and future potential in biotechnology and medicine.

Main Methods:

• Review of literature on pVLP characteristics and applications.
• Analysis of pVLP size, shape, and surface charge effects on cellular interactions.
• Examination of host range, biosafety, and production scalability.

Main Results:

• pVLP size and shape critically influence cellular uptake, biodistribution, and clearance.
• Surface charge and modifications impact VLP-cell interactions, affecting targeting and stability.
• Scalability of pVLP production presents both challenges and opportunities for large-scale manufacturing.

Conclusions:

• pVLPs are versatile tools with significant potential in vaccine development, targeted therapies, and diagnostics.
• Careful consideration of pVLP design factors is essential for successful biomedical applications.
• Further research and development can unlock the full potential of pVLPs in biotechnology and medicine.