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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Optimizing Intranasal Amisulpride Loaded Nanostructured Lipid Carriers: Formulation, Development, and
Manar Adnan Tamer1, Hanan Jalal Kassab1
1Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq.
Pharmaceutical Nanotechnology
|February 26, 2025
Summary
This study developed intranasal nanostructured lipid carriers (NLCs) for amisulpride, enhancing its dissolution and bioavailability. The optimized NLC formulation demonstrated favorable characteristics and safety for nasal delivery.
Area of Science:
- Pharmaceutical Sciences
- Nanotechnology
- Drug Delivery
Background:
- Nanostructured lipid carriers (NLCs) are advanced lipid-based nanoparticles.
- NLCs consist of solid and liquid lipids stabilized by surfactants.
- They offer potential for improved drug delivery systems.
Purpose of the Study:
- To formulate intranasal nanostructured lipid carriers (NLCs) loaded with amisulpride.
- To enhance the dissolution and bioavailability of amisulpride via intranasal delivery.
- To optimize NLC formulations by varying lipid and surfactant compositions.
Main Methods:
- Amisulpride NLCs were prepared using ultrasonication.
- Various solid lipids (stearic acid, palmitic acid, glyceryl monostearate) and liquid lipids (oleic acid, Imwitor 988, isopropyl myristate) were used.
- Surfactants (cremophor®EL, tween 80, span 20) and co-surfactants (Transcutol HP, triacetin, propylene glycol) were evaluated.
Main Results:
- Formulation composition significantly impacted NLC characteristics like particle size, zeta potential, and entrapment efficiency.
- The optimal formulation (F19) exhibited a particle size of 68.309 nm, zeta potential of -20.64 mV, and high entrapment efficiency (95.75%).
- A biphasic drug release pattern was observed, and the formulation was found safe on sheep nasal membranes.
Conclusions:
- Optimized intranasal NLCs offer a promising approach for amisulpride delivery.
- Careful selection of formulation components is crucial for successful amisulpride-loaded NLCs.
- This strategy enhances drug dissolution and bioavailability for nasal administration.
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