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Related Experiment Video

Updated: May 25, 2025

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

Published on: April 26, 2019

A RARE PRESENTATION OF TWO COLORECTAL ANOMALIES: ANORECTALMALFORMATION CO-EXISTING WITH HIRSCHSPRUNG'S DISEASE IN

K I Egbuchulem¹, T A Lawal^1,2, O O Ogundoyin^1,2

¹Division of Paediatric Surgery, Department of Surgery, University College Hospital, Ibadan.

Annals of Ibadan Postgraduate Medicine

|February 26, 2025

Summary

This case study highlights the rare association between Hirschsprung

Keywords:

Anorectal malformation Coexisting anomalies Hirschsprung's Ibadan Nigerian.

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Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

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Published on: June 10, 2022

Area of Science:

Pediatric Surgery
Gastroenterology
Genetics

Background:

Hirschsprung's disease (HD) and anorectal malformation (ARM) co-occurrence is rare and challenging.
ARM repair symptoms can mask underlying HD, worsening post-stoma closure.
This association necessitates a high index of suspicion for timely diagnosis.

Purpose of the Study:

To report a rare case of HD associated with ARM.
To highlight diagnostic and surgical management challenges.
To emphasize the need for increased awareness of this association.

Main Methods:

Case report of a 7-year-old boy with high ARM and subsequent HD diagnosis.
Details of surgical interventions including diverting colostomy, PSARP, levelling colostomy, and Swenson's pull-through.
Management of postoperative complications, including a colo-urethral fistula.

Main Results:

Delayed HD diagnosis due to initial ARM treatment.
Multiple surgical procedures required for management.
Postoperative complications, including fistula formation, necessitating further interventions.
Patient experienced frequent bowel movements post-final surgery.

Conclusions:

The association of HD with ARM is infrequent but clinically significant.
Delayed diagnosis and management lead to increased morbidity.
Early recognition and a high index of suspicion are crucial for optimal patient outcomes.