Related Experiment Video

Updated: May 25, 2025

Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
09:48

Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology

Published on: February 25, 2022

4.0K

Central precocious puberty associated with duplicated pituitary: a case report and literature review

Kun Yang1, Yanmei Sang2,3, Li Dai1

  • 1Baoding Hospital, Beijing Children's Hospital affiliated to Capital Medical University, Baoding, Hebei, China.

Frontiers in Endocrinology
|February 26, 2025
PubMed

Insights

This case study details a young girl with pituitary duplication presenting with central precocious puberty (CPP). Treatment with gonadotropin-releasing hormone analogue (GnRHa) effectively delayed puberty and improved predicted adult height.

Area of Science:

  • Endocrinology
  • Pediatric Endocrinology
  • Neuroendocrinology

Background:

  • Pituitary duplication is a rare congenital anomaly associated with significant neurodevelopmental and craniofacial issues.
  • Central precocious puberty (CPP) is an uncommon manifestation of pituitary duplication, with only eight cases previously reported.
  • Early diagnosis and intervention are crucial for managing CPP and optimizing long-term outcomes.

Purpose of the Study:

  • To report a case of pituitary duplication presenting with central precocious puberty (CPP) in a pediatric patient.
  • To describe the clinical presentation, diagnostic findings, and treatment response in this rare condition.
  • To highlight the efficacy of gonadotropin-releasing hormone analogue (GnRHa) therapy in managing CPP associated with pituitary duplication.

Main Methods:

  • A 6-year-old girl presented with clinical signs of precocious puberty.
  • Magnetic Resonance Imaging (MRI) revealed a duplicated pituitary gland.
  • Gonadotropin-releasing hormone analogue (GnRHa) stimulation test confirmed CPP.
  • Treatment with GnRHa was initiated.

Main Results:

  • The patient exhibited classic symptoms of CPP, including breast development, accelerated growth, advanced bone age, and elevated hormone levels.
  • MRI confirmed the presence of a duplicated pituitary gland.
  • The GnRHa stimulation test was positive, indicating central precocious puberty.
  • Following 2 years of GnRHa treatment, the patient showed delayed progression of sexual development, reduced CPP symptoms, and an improved predicted adult height.

Conclusions:

  • Pituitary duplication can present with central precocious puberty (CPP) in pediatric patients.
  • GnRHa therapy is an effective treatment for CPP in the context of pituitary duplication.
  • This case underscores the importance of considering rare anatomical variations in the diagnosis and management of pediatric endocrine disorders.

Keywords:
GnRHacentral precocious puberty (CPP)duplicated pituitaryfemaleheight

More Related Videos

Dissection and Coronal Slice Preparation of Developing Mouse Pituitary Gland06:53

Dissection and Coronal Slice Preparation of Developing Mouse Pituitary Gland

Published on: November 16, 2017

17.3K
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

11.1K

Related Concept Videos

Centrosome Duplication02:25

Centrosome Duplication

The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
3.9K
Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
213
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.3K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.3K
Hormones of the Pituitary Gland01:27

Hormones of the Pituitary Gland

The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
6.2K