Hepatobiliary organoid research: the progress and applications

Area of Science:

• Life Sciences
• Biotechnology
• Organoid Technology

Background:

• Organoid culture technology enables the creation of "in vitro micro-organs" that mimic native tissue structure and function.
• Organoids serve as crucial preclinical models for disease research and therapeutic development.
• Hepatobiliary diseases remain a significant challenge, necessitating improved research models and treatment strategies.

Purpose of the Study:

• To introduce organoid definition and advantages.
• To describe the development and advances in hepatobiliary organoids research.
• To highlight the application of hepatobiliary organoids in disease research, drug discovery, and regenerative medicine.

Main Methods:

• Review of organoid culture technology.
• Focus on hepatobiliary organoids.
• Discussion of applications in liver and biliary tract diseases.

Main Results:

• Organoids faithfully recapitulate organogenesis, structure, function, and pathology.
• Hepatobiliary organoids are valuable for studying benign and malignant diseases.
• Organoid technology provides a new avenue for addressing challenges in hepatobiliary research.

Conclusions:

• Organoid culture technology is a promising tool for advancing hepatobiliary disease research and treatment.
• Despite current limitations, organoids offer significant potential for drug research and regenerative medicine.
• Integration with technologies like CRISPR-HOT and organ-on-a-chip may enhance future organoid development.