Downregulation of DNAJC12 Expression Predicts Worse Survival for ER-Positive Breast Cancer Patients
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View abstract on PubMed
Summary
This summary is machine-generated.DNAJC12 (DnaJ heat shock protein family (Hsp40) member C12) expression is a potential biomarker for breast cancer (BC). Low DNAJC12 mRNA and protein levels indicate a worse prognosis and predict treatment response in BC patients.
Area Of Science
- Molecular Biology
- Oncology
- Biomarker Discovery
Background
- DNAJC12 (DnaJ heat shock protein family (Hsp40) member C12) is a molecular chaperone involved in protein folding and proteostasis.
- Its utility as a biomarker is established for limited cancer types.
- The study investigates DNAJC12's potential in breast cancer (BC).
Purpose Of The Study
- To evaluate DNAJC12 mRNA and protein expression as prognostic and predictive biomarkers for breast cancer (BC).
- To correlate DNAJC12 expression with clinicopathological features and treatment response in BC.
Main Methods
- In silico analysis of publicly available data.
- Immunohistochemistry (IHC) analysis of DNAJC12 protein expression in 292 primary BC samples.
- Correlation of DNAJC12 expression with clinicopathological characteristics, survival outcomes, and treatment responsiveness.
Main Results
- DNAJC12 transcripts were differentially expressed based on ER, PR, HER2 status, and molecular subtype.
- Low DNAJC12 mRNA expression correlated with worse overall survival, disease-free survival, and treatment response.
- Low DNAJC12 protein expression was associated with poorer prognosis across all BC subtypes and Luminal BC.
- DNAJC12 protein levels differed significantly with tumor size and lymph node involvement.
Conclusions
- DNAJC12 shows potential as a prognostic biomarker in breast cancer.
- DNAJC12 expression may serve as a predictive biomarker for treatment response in BC.
- Further investigation into DNAJC12's role in BC is warranted.
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