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Glomerulonephritis with Positive Anti-Glomerular Basement Membrane Antibodies following COVID-19 Vaccine
Presentation:
A 78 year old female presented to the emergency department with a one day history of haemoptysis, cough, fever and shortness of breath. This was two days after the second dose of her Covid-19 mRNA vaccine.
Diagnosis:
A diagnosis of vaccine-mediated anti-glomerular basement membrane antibody (anti-GBM) disease (or Goodpasture's Syndrome) was made after a vasculitic screen was sent for suspected glomerulonephritis.
Treatment:
She was treated with IV Methylprednisolone 1000mg IV for three days, seven sequential sessions of plasmapheresis and pulsed IV Cyclophosphamide, with resolution of haemoptysis and kidney function.
Discussion:
It is important to maintain a high index of suspicion and test for anti-GBM disease in patients receiving SARS-CoV-2 mRNA vaccination.
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