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Updated: May 25, 2025

Establishing a Device for Sleep Deprivation in Mice
Published on: September 22, 2023
Enhanced Pain Sensitization Induced by Chronic Sleep Deprivation: The Role of Dopamine D2 Receptors-Dependent Homer1a
Chao Fu1, Peng Wu1, Fancan Wu2
1Department of Anesthesiology, Jinan University First Affiliated Hospital, Number 613, The West of Huangpu Avenue, Tianhe Region, Guangzhou 510630, Guangdong, China.
Abstract:
Numerous studies have demonstrated a positive correlation between sleep disorders and hyperalgesia. These sleep disorders adversely affect the descending pain regulatory system. Researchers have extensively studied the midbrain dopamine system in relation to pain associated with sleep disturbances. Our study shows that chronic sleep deprivation decreases dopamine responses to noxious stimuli within the mouse nucleus accumbens, regulated by dopamine release and intracellular signals. Furthermore, we confirmed that the dopamine D2 receptors play a critical role in the pain associated with chronic sleep deprivation. Importantly, we revealed that homer1a in D2 receptor neurons enhances AMPA receptors expression.
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