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Promoting Diversity through an Understanding of Barriers and Drivers for Inclusive Clinical Trials
Annick de Bruin1, Jasmine Masullo1, Shalome Sine2
1The Center for Information and Study on Clinical Research Participation, Boston, MA, USA.
Therapeutic Innovation & Regulatory Science
|February 26, 2025
Summary
Clinical trial diversity is crucial for equitable healthcare. This global survey identified unique barriers faced by underrepresented ethnic groups, emphasizing the need for inclusive trial designs to improve participation and outcomes.
Area of Science:
- Clinical trial diversity and inclusion
- Health equity research
- Patient-centered trial design
Background:
- Equitable representation in clinical trials is vital for drug development and healthcare outcomes.
- Understanding barriers and drivers for inclusive trials is essential, particularly for underrepresented populations.
Purpose of the Study:
- To investigate the attitudes, perceptions, experiences, and challenges influencing clinical trial participation among diverse racial and ethnic groups.
- To identify specific barriers to clinical research access and participation across different ethnicities.
Main Methods:
- A global online survey was conducted from April to June 2023, with 12,017 respondents from 54 countries.
- Participants were recruited via patient organizations and advocacy groups, with eligibility for adults 18+ with online access.
- Statistical analysis compared responses on perceptions, concerns, and experiences related to clinical trials among racial and ethnic groups.
Main Results:
- Barriers to clinical trial participation varied significantly by ethnicity.
- Asian respondents were more concerned about work time and time commitment; Hispanic respondents worried about time off work and receiving placebo.
- Black and Hispanic respondents prioritized staff diversity more than White respondents, and Black, Asian, and Hispanic participants reported greater disruption from technology and home-based study requirements.
Conclusions:
- Findings underscore the necessity of addressing diversity barriers in clinical trials.
- Improving the trial experiences of underrepresented communities is key to designing more inclusive and patient-centered studies.
- Tailored strategies are needed to overcome ethnicity-specific challenges and promote equitable participation in clinical research.
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