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Amphiphilic Acyclic Cucurbit[n]uril: Synthesis, Self-Assembly, and Chemotherapeutic Delivery to Overcome Multidrug
Zizhen Zhao1, Danying Ma1, Shuyi Wang1
1Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
Abstract:
A new amphiphilic acyclic cucurbit[n]uril (CB[n]) is designed and synthesized. This amphiphilic acyclic CB[n] could encapsulate pharmaceutical drugs via a host-guest interaction. Self-assembly of this acyclic CB[n] forms spherical nanoparticles with diameters of 91 nm in water. The self-assembled nanoparticles are capable of delivering doxorubicin with high efficiency. Cell experiments show that the doxorubicin-loaded nanoparticles can improve cellular uptake and cytotoxicity by using the MCF-7/ADR cell line. The A549 tumor-bearing mouse model shows that self-assembled nanoparticles help overcome multidrug resistance in vivo. Cell study and histological assays confirm the biocompatibility of self-assembled nanoparticles.
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