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An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
Epidemiology of glomerular diseases in a Colombian population
Joaquín Rodelo-Ceballos1, Wilson Fernando Chávez-Gómez2, Alejandra Taborda-Murillo3
1Nephrology Division, Internal Medicine Department, School of Medicine, Hospital Universitario de San Vicente Fundación, Universidad de Antioquia, Medellín, Colombia.
Insights
Glomerular diseases like lupus nephritis and FSGS are common, particularly in women. Renal biopsies reveal disease patterns influenced by age and sex, with nephrotic syndrome as a key diagnostic indicator.
Area of Science:
- Nephrology
- Pathology
- Epidemiology
Background:
- Glomerular diseases encompass diverse conditions with varied presentations and pathophysiology.
- Renal biopsy is crucial for accurate diagnosis and prognosis.
- Understanding epidemiology aids in targeted treatment strategies.
Purpose of the Study:
- To analyze the epidemiology of glomerular diseases.
- To describe histopathological findings from renal biopsies.
- To investigate disease patterns in Colombia from 1988-2023.
Main Methods:
- Retrospective, descriptive, cross-sectional study design.
- Analysis of 4567 renal biopsy histopathology reports.
- Evaluation of sociodemographic, clinical, and laboratory data.
Main Results:
- Women comprised 56.6% of patients; average age was 32 years.
- Lupus nephritis (28.2%) and focal segmental glomerulosclerosis (16.6%) were most prevalent.
- Nephrotic syndrome (35.0%) was the primary indication for biopsy.
Conclusions:
- Glomerular disease types vary by age and sex.
- Lupus nephritis and FSGS are the most common diagnoses.
- Nephrotic syndrome and abnormal urinary sediment are key biopsy indications.
Background:
Glomerular diseases are a diverse group of conditions with variations in clinical presentation, pathophysiology, diagnosis, and treatment. Renal biopsy is essential for determining their aetiology and prognosis.
Objective:
To describe the epidemiology of glomerular diseases based on histopathological studies conducted in the Department of Pathology at the School of Medicine, University of Antioquia, Colombia, between 1988 and 2023.
Materials And Methods:
A retrospective, descriptive, cross-sectional study was conducted on patients with glomerular disease who underwent renal biopsy between 1988 and 2023. A descriptive analysis was performed on their sociodemographic, clinical, laboratory, and pharmacological characteristics.
Results:
A total of 4567 histopathology reports were analysed. Of these, 56.6% were from women, with an average age of 32 years. Nephrotic syndrome was the most common indication for renal biopsy (35.0%). Lupus nephritis was the most prevalent diagnosis (28.2%), followed by focal segmental glomerulosclerosis (16.6%). In adults, lupus nephritis and focal segmental glomerulosclerosis were the most frequent diagnoses, while in children, minimal change disease and focal segmental glomerulosclerosis were the most common.
Conclusions:
The type of glomerular disease varies according to sociodemographic factors such as age and sex. Lupus nephritis and focal segmental glomerulosclerosis were the most common glomerular diseases. The main indications for biopsy were nephrotic syndrome and abnormal urinary sediment.
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