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Bidirectional association between sarcopenia and depression: A systematic review and meta-analysis
Xiangpeng Meng1, Ze Wang1, Linyu Lyu2
1Medical School, Changchun Sci-Tech University, Changchun, Jilin, 130600, China.
Archives of Gerontology and Geriatrics
|February 26, 2025
Summary
This study confirms a strong link between sarcopenia and depression, showing each condition increases the risk of developing the other. This bidirectional relationship is crucial for improving prevention and treatment strategies.
Area of Science:
- Gerontology
- Psychiatry
- Public Health
Background:
- Sarcopenia, age-related muscle loss, and depression are prevalent conditions.
- A potential bidirectional association between sarcopenia and depression has been suggested but lacks systematic evidence.
Purpose of the Study:
- To systematically evaluate the bidirectional association between sarcopenia and depression.
- To provide evidence for developing targeted prevention and control strategies.
Main Methods:
- A comprehensive literature search was conducted across PubMed, Embase, Cochrane, and Web of Science.
- Quality assessment used the Newcastle-Ottawa Scale and JBI Critical Appraisal Checklist.
- Meta-analysis and subgroup analyses were performed using R 4.4.1.
Main Results:
- Thirty-three studies with 119,421 participants were included.
- A significant bidirectional relationship was found between sarcopenia and depression in community populations.
- Sarcopenia increased depression risk (OR=2.40), and depression increased sarcopenia risk (OR=1.90). Depressive symptoms also increased sarcopenia risk (OR=1.38).
Conclusions:
- The bidirectional association between sarcopenia and depression is significant.
- This finding supports improved prevention, screening, diagnosis, and treatment of depression.
- Addressing this link can enhance quality of life and health outcomes.
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