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Updated: May 25, 2025

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure
Published on: October 1, 2019
Sensor platform for noninvasive evaluation of pulmonary oxidative status
Egor A Andreev1, Vera A Shavokshina1, Vita N Nikitina1
1Chemistry Faculty of M.V. Lomonosov Moscow State University, 119991, Moscow, Russia.
Abstract:
We report on sensor platform including both the advanced nanostructured Prussian Blue based hydrogen peroxide sensor and the cooling-free breath aerosol (BA) condenser. The latter provides an order of magnitude more concentrated BA samples as compared to breath condensate collected traditionally through cooling; the conclusion is based on both: specimen's conductivity, the generally accepted dilution marker, and the evaluated H2O2 levels (2.2-3.2 μM for healthy subjects). Reliable detection of submicromolar H2O2 content is possible with the sensor based on nanostructured Prussian Blue (0.45-0.70 nmol cm-2) stabilized with nickel hexacyanoferrate (1.0-1.3 nmol cm-2). A possibility to discover the noninvasively accessed marker for post-COVID-19 syndrome illustrates the horizons of the platform in clinical diagnostics.
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