Lipid-based nanocarriers loaded with bioactive compounds in active food packaging: Fabrication, characterization, and...

New trends in the food industry emphasize safer, more stable, eco-friendly, and value-added packaging solutions. Active packaging has emerged to release or absorb bioactive components, which are often sensitive to physical, chemical and/or enzymatic factors as well as being unstable. Lipid-based nanocarriers (nanoemulsions, nanoliposomes, solid lipid nanoparticles and nanostructured lipid carriers) have demonstrated their industrial potential and efficiency in the uptake, protection, bioavailability and controlled/targeted release of a wide variety of water-soluble, fat-soluble or amphiphilic bioactive substances. Additionally, their reduced size and consequently, high surface-to-volume ratio, give them unique physicochemical attributes, novel characteristics in the final product and biocompatibility as well as adhesion strength with the food packaging, without altering the sensory attributes of the food. Despite these benefits, challenges related to stability, regulatory concerns, and large-scale production must be addressed. This review examines the fabrication, characterization, and application of lipid-based nanocarriers in active food packaging, emphasizing their benefits, challenges, and future potential while further exploring their successful integration into the food packaging industry.