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Prognostic Significance of Programmed Cell Death-1, Programmed Cell Death-Ligand 1, Programmed Cell Death-Ligand 2,
Ana Blanca1,2,3, Antonio Lopez-Beltran1, Enrique Gomez-Gomez2,3
1Department of Morphological Sciences, University of Cordoba Medical School, Cordoba, Spain.
Summary
High programmed cell death (PD)-1/PD-L1/PD-L2 expression indicates poor bladder cancer prognosis. Reduced fibroblast growth factor receptor 3 (FGFR3) expression also predicts worse outcomes, suggesting their use as prognostic biomarkers.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Bladder cancer (BC) prognosis is influenced by various molecular markers.
- Programmed cell death (PD)-1/PD-L1/PD-L2 and fibroblast growth factor receptor 3 (FGFR3) are implicated in cancer progression.
Purpose of the Study:
- To evaluate the prognostic significance of PD-1/PD-L1/PD-L2 and FGFR3 expression in bladder cancer.
- To identify potential biomarkers for predicting BC patient outcomes.
Main Methods:
- Retrospective analysis of 105 bladder cancer patients.
- Quantitative reverse transcription PCR and NanoString technology used to assess mRNA levels of PD-1/PD-L1/PD-L2 and FGFR3.
Main Results:
- High PD-1/PD-L1/PD-L2 expression correlated with higher tumor stage, grade, and cancer-specific mortality.
- High FGFR3 expression was linked to improved survival and favorable clinicopathological features.
- Low FGFR3 expression and high PD-1/PD-L1/PD-L2 expression were associated with worse cancer-specific survival. Advanced stage, low FGFR3, and high PD-L2 independently predicted poor prognosis.
Conclusions:
- Elevated PD-1, PD-L1, and PD-L2 levels, along with reduced FGFR3 expression, are associated with poor prognosis in bladder cancer.
- These markers may serve as valuable prognostic biomarkers for identifying high-risk BC patients.
Keywords:
Bladder cancerFibroblast growth factor receptor 3Prognostic significanceProgrammed cell death-1Programmed cell death-ligand 1/programmed cell death-ligand 2Therapeutic strategyMore Related Videos
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