Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autophagy01:27

Autophagy

4.1K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.1K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

6.1K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
6.1K
Autophagic Cell Death01:18

Autophagic Cell Death

3.0K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
3.0K
The Synapse02:47

The Synapse

122.4K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
122.4K
Neural Regulation01:37

Neural Regulation

39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
Integration of Synaptic Events01:28

Integration of Synaptic Events

1.4K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biological performance evaluation of graphene nanoplatelets for intracranial direct current stimulation.

Frontiers in neuroscience·2026
Same author

Standard-dose unfractionated heparin versus low-dose unfractionated heparin and low-molecular-weight heparin in extracorporeal life support (RATE): an open-label, randomised, non-inferiority trial.

Lancet (London, England)·2026
Same author

SEMI-1, A Novel Neuronal Selenium-Binding Protein 1 Homolog Without Methanethiol Oxidase Activity, Modulates Stress Resistance, Lifespan, and Thermotaxis in C. elegans.

BioFactors (Oxford, England)·2026
Same author

Contextual fear conditioning leads to hypo-innervation of the left ventricular myocardium in female but not male C57BL/6J mice.

IBRO neuroscience reports·2026
Same author

The Influence of Environmental Fidelity on Virtual Presence, Intrinsic Motivation, Cognitive Load and Learning Outcomes in Medical VR.

IEEE transactions on visualization and computer graphics·2026
Same author

Nanoscale Mapping Reveals Periodic Organization of Neutrophil Extracellular Trap Proteins.

Nano letters·2026

Related Experiment Video

Updated: May 25, 2025

An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins
09:33

An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins

Published on: June 26, 2018

7.4K

Neuronal autophagy in the control of synapse function.

Anna Karpova1, P Robin Hiesinger2, Marijn Kuijpers3

  • 1Leibniz Institute for Neurobiology (LIN), 39118 Magdeburg, Germany; Center for Behavioral Brain Sciences, Otto-von-Guericke-University, 39120 Magdeburg, Germany.

Neuron
|February 26, 2025
PubMed
Summary
This summary is machine-generated.

Autophagy is crucial for neuron health, clearing cellular waste to maintain brain function. Disruptions in this process are linked to neurological diseases, highlighting its importance in synaptic integrity and function.

Keywords:
autophagymemoryneurological diseasesneurotransmissionsynapsesynaptic plasticity

More Related Videos

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.1K
Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons
10:50

Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons

Published on: November 2, 2018

50.9K

Related Experiment Videos

Last Updated: May 25, 2025

An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins
09:33

An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins

Published on: June 26, 2018

7.4K
A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.1K
Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons
10:50

Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons

Published on: November 2, 2018

50.9K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Genetics

Background:

  • Neurons rely on autophagy to clear toxic proteins and organelles, preserving proteome integrity and neurotransmission.
  • Defects in autophagy genes are implicated in congenital diseases with severe brain dysfunction, including epilepsy and neurodegeneration.
  • Autophagy is essential for normal behavior, synapse maturation, plasticity, and neurotransmitter release.

Purpose of the Study:

  • To summarize current knowledge on neuronal autophagy.
  • To address controversies and inconsistencies regarding autophagy's role in synaptic function.
  • To provide a future research roadmap for neuronal autophagy and synaptic control.

Main Methods:

  • Literature review and synthesis of existing research on neuronal autophagy.
  • Analysis of studies investigating the impact of autophagy gene mutations and ablation on neuronal and behavioral function.
  • Identification of key controversies and areas requiring further investigation.

Main Results:

  • Autophagy is vital for maintaining neuronal health and function, impacting behavior and synaptic processes.
  • Dysfunctional autophagy contributes to neurological disorders, affecting synapse maturation, plasticity, and neurotransmitter release.
  • Significant gaps and controversies exist regarding specific substrates and mechanisms of neuronal autophagy.

Conclusions:

  • Autophagy plays a critical role in neuronal homeostasis and synaptic function.
  • Further research is needed to resolve controversies and elucidate the precise mechanisms of neuronal autophagy in health and disease.
  • Understanding neuronal autophagy is key to developing therapeutic strategies for associated neurological disorders.