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The new perspective of gasotransmitters in cancer metastasis

Yu-Bo Shi1, Lin Cheng2, Yue Lyu3

  • 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Department of Thyroid and Breast Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Nitric Oxide : Biology and Chemistry
|February 26, 2025
PubMed

Insights

Gasotransmitters like nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are involved in cancer metastasis. Understanding their roles may lead to new cancer treatment strategies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Cancer metastasis is a primary cause of cancer-related mortality.
  • Gasotransmitters (nitric oxide, carbon monoxide, hydrogen sulfide) are implicated in various physiological and pathological processes, including cancer.
  • Abnormal expression of gasotransmitters and their enzymes occurs in cancer, suggesting a role in disease progression.

Purpose of the Study:

  • To review the nature of gasotransmitters.
  • To summarize research on gasotransmitter-induced cancer metastasis.
  • To elucidate the mechanisms by which gasotransmitters modulate cancer metastasis.

Main Methods:

  • Literature review of existing research on gasotransmitters and cancer metastasis.
  • Analysis of signaling pathways and molecular mechanisms involved.

Main Results:

  • Gasotransmitters play significant roles in cancer metastasis.
  • These gases modulate diverse signaling axes to promote metastasis.
  • Abnormal expression of gasotransmitters and associated enzymes is linked to cancer progression.

Conclusions:

  • Gasotransmitters are critical players in cancer metastasis.
  • Elucidating gasotransmitter functions offers potential therapeutic targets for cancer management.
  • Further research into gasotransmitter mechanisms can advance cancer treatment strategies.
Keywords:
Cancer metastasisCarbon monoxide (CO)GasotransmitterHydrogen sulfide (H(2)S)Nitric oxide (NO)

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