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Updated: May 25, 2025

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
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Vaping cessation interventions: a systematic review and meta-analysis.

Javad Heshmati1, Avinash Pandey1,2, Joseph Benjamen2

  • 1University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Tobacco Control
|February 26, 2025
PubMed
Summary
This summary is machine-generated.

Vaping cessation interventions significantly boost 7-day abstinence rates, offering hope for quitting electronic nicotine delivery systems (ENDS). More research is needed to confirm long-term effectiveness and guide clinical practice.

Keywords:
CessationElectronic nicotine delivery devicesNicotineVaping cessation

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Area of Science:

  • Public Health
  • Addiction Medicine
  • Clinical Research

Background:

  • Electronic nicotine delivery systems (ENDS), or e-cigarettes, have rapidly gained popularity.
  • Known risks of ENDS include nicotine addiction, lung injury, and potential cardiovascular, immune, and neurodevelopmental effects.
  • Effective strategies for ENDS addiction treatment are lacking, with no approved cessation aids currently available.

Purpose of the Study:

  • To systematically review and synthesize the existing literature on interventions designed to aid vaping cessation.
  • To evaluate the efficacy of various interventions in helping individuals quit using electronic nicotine delivery systems.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases (MEDLINE, Embase, Scopus) and grey literature sources up to January 2024.
  • Included studies were randomized controlled trials (RCTs) assessing vaping cessation rates.
  • Meta-analyses were performed using an intention-to-treat approach to determine the odds of abstinence.

Main Results:

  • Seven RCTs involving pharmacological therapy, digital interventions, and educational content were analyzed.
  • Interventions significantly increased the odds of achieving 7-day point prevalence abstinence (PPA) (OR 1.52).
  • A significant increase in continuous abstinence was also observed (OR 2.71), though 30-day PPA showed non-significant results.

Conclusions:

  • Vaping cessation interventions effectively increase 7-day PPA rates at 1-12 months post-intervention.
  • The positive effects were consistent across different intervention types, outcomes, and follow-up durations.
  • Further high-quality research is recommended to strengthen evidence and inform clinical guidelines for vaping cessation.