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Related Concept Videos

Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
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Related Experiment Video

Updated: May 25, 2025

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
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Cellular Membrane Protein GRINA is Highly Expressed and Associated with Survival Outcomes in Liver Cancer Patients.

Jun-Bo Song1, Shan-Shan Guo2, Wen-Jie Gao1

  • 1Department of Hepatobiliary Surgery, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China.

Current Medical Science
|February 26, 2025
PubMed
Summary

This study identifies ferroptosis-related genes and develops a prognostic model for hepatocellular carcinoma (HCC). GRINA gene suppression induces ferroptosis, offering a potential therapeutic strategy for HCC.

Keywords:
FerroptosisGRINAHepatocellular carcinomaNomogramPrognostic signature

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Area of Science:

  • Oncology
  • Cell Death Mechanisms
  • Genomics

Background:

  • Hepatocellular carcinoma (HCC) is a deadly cancer with high global mortality.
  • Ferroptosis, an iron-dependent cell death, presents a potential therapeutic target for HCC.
  • The prognostic significance of ferroptosis in HCC remains largely unexplored.

Purpose of the Study:

  • To identify ferroptosis-related genes in HCC.
  • To develop a prognostic model for HCC patients based on ferroptosis.
  • To investigate the therapeutic potential of targeting ferroptosis, specifically the GRINA gene.

Main Methods:

  • Utilized single-cell and bulk sequencing data to identify ferroptosis-related genes.
  • Developed a prognostic model using Cox and LASSO regression analyses.
  • Conducted functional assays to assess the role of GRINA in HCC cell proliferation, metastasis, and ferroptosis induction.

Main Results:

  • A ferroptosis-related prognostic model was established, classifying HCC patients into distinct risk groups with survival disparities.
  • High-risk patients exhibited increased immune checkpoint gene expression, and the nomogram demonstrated strong prognostic accuracy.
  • GRINA suppression inhibited HCC cell proliferation and metastasis, inducing mitochondrial abnormalities, increased intracellular iron, and ROS levels, indicative of ferroptosis.

Conclusions:

  • Established a link between ferroptosis-related risk groups and the tumor immune microenvironment in HCC using multiomics data.
  • GRINA inhibition emerges as a potential therapeutic strategy for HCC, inducing ferroptosis through mitochondrial damage.