[Effect of tensides on the dissolution rate and crystal pattern of propylphenazone]

Propyphenazone has been recrystallized from different polarity solvents by means of various non-ionic tensides (Tween 20 and 80, Brij 35 and Myrj 51) and the ionic sodium lauryl sulphate. The tenside amount adsorbed by propyphenazone could be determined by measurements of the surface tension. Differences between the adsorption of the non-ionic tensides and the ionic product could be stated. Differences of the crystal areas can be eliminated by adding tensides to polar and apolar solvents. All the recrystallization products distinguish by a significant increase of the dissolution rate.