Behavioral and pathological characteristics of 5xFAD female mice in the early stage

Alzheimer's disease (AD) is a central nervous system degenerative disease with insidious onset and gradual development caused by selective and progressive loss of neurons. The 5xFAD mouse is a relatively mature disease model of AD. However, the behavioral research on 5xFAD female mouse is more focused on the changes of late memory function, and the exploration of its early behavioral and pathological changes is still incomplete. This research aims to explore the changes in memory function, emotional function (including anxiety and depression), motor ability, amyloid plaques, glial cell response and neurogenesis in the hippocampus of female 5xFAD mice in the early stage, laying a foundation for a comprehensive exploration of the disease mechanism of AD. The results of this study found that early 4-month-old female 5xFAD mice mainly showed a decline in memory function without other dysfunction. Accompanied by a large amount of amyloid protein plaques deposited in the hippocampus, it induced the response of microglia and astrocytes, and neurogenesis decreased significantly with age, especially in early female 5xFAD mice, which resulted in a decrease in the number of new neurons. This may be an important reason for the decline in memory function of female 5xFAD mice in the early stage.