Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prolonged ethanol consumption influences shuttle box and passive avoidance performance in rats.

C Guaza, J Borrell

    Physiology & Behavior
    |February 1, 1985
    PubMed
    Summary

    Chronic ethanol consumption in rats led to long-term deficits in learning and memory, even weeks after alcohol intake ceased. These findings highlight persistent neurotoxic effects of alcohol on cognitive functions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Supplementing Silicoglycidol for the reduction of aflatoxin M<sub>1</sub> in milk and biomarkers of liver dysfunction in dairy cows.

    JDS communications·2024
    Same author

    Post-ischemic reorganization of sensory responses in cerebral cortex.

    Frontiers in neuroscience·2023
    Same author

    Post-Ischemic Reorganization of Sensory Responses in Cerebral Cortex.

    bioRxiv : the preprint server for biology·2023
    Same author

    The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia.

    Brain, behavior, and immunity·2018
    Same author

    Gut microbiota, cannabinoid system and neuroimmune interactions: New perspectives in multiple sclerosis.

    Biochemical pharmacology·2018
    Same author

    Gut dysbiosis and neuroimmune responses to brain infection with Theiler's murine encephalomyelitis virus.

    Scientific reports·2017

    Area of Science:

    • Neuroscience
    • Behavioral Science
    • Toxicology

    Background:

    • Chronic alcohol consumption is a widespread issue with known neurological consequences.
    • Understanding the long-term impact of alcohol on cognitive functions is crucial for public health.
    • Investigating the persistence of alcohol's effects after cessation is important for treatment strategies.

    Purpose of the Study:

    • To investigate the long-term effects of chronic ethanol exposure on learning and memory in rats.
    • To assess behavioral changes in animals after a period of alcohol abstinence.

    Main Methods:

    • Rats were administered a chronic ethanol liquid diet for 16 days.
    • Following a 3-week withdrawal period, animals underwent behavioral testing.
    • Tests included shuttle box avoidance (acquisition) and passive avoidance (retention).

    Related Experiment Videos

    Main Results:

    • Rats exposed to ethanol showed significant impairment in acquiring the shuttle box avoidance task.
    • A slight impairment was observed in the retention of the passive avoidance response.
    • These cognitive deficits persisted three weeks after ethanol cessation.

    Conclusions:

    • Ethanol and its metabolites can induce lasting negative effects on learning and memory.
    • Neurotoxic effects on cognitive processes can endure even after alcohol consumption stops.
    • This study underscores the potential for long-term cognitive impairment following chronic alcohol abuse.